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KMID : 0385219940040010051
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Korean Journal of Gerontology
1994 Volume.4 No. 1 p.51 ~ p.55
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Effect of Codonopsis lanceolata Extract on Physiological Activity of Rats
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Kim Chang-Mok
Choi Jin-Ho
Oh Sung-Ki
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Abstract
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Sprague-Dawley(SD) male rats were fed high cholesterol diet, and also were orally administered with 0(CL-0), 100(CL-100), 200(CL-200), and 400(CL-400)㎎/㎏ BW of codonopsis lanceolata(CL)extract for 4 weeks in order to examine the effect of the extract on body weight, triglyceride and cholesterol, LDL and HDL cholesterols, atherogenic index, and lipid peroxides in serum of rats. Body weight gain and gross efficiency were slightly inhibited with the increase of CL extract administered orally. Administrations of CL extract resulted in a remarked decreases in triglycerides (30.0∼48.2%), total cholesterols (17.2∼27.7%) and LDL cholesterols (16.4∼19.0%) in serum. HDL cholesterol levels in serum of CL-100, CL-200 and CL-400 groups were significantly increased by 7.2%, 14.0%, and 24.8%, respectively, compared with control group of CL-0 (p<0.01∼0.001). Atherogenic index in serum of CL-100, CL-200 and CL-400 groups also were remarkably inhibited by 30.1%, 41.7% and 56.6%, respectively, compared with control group (p<0.001). Serum malondialdehyde levels as a lipid peroxide effectively inhibited withdises of CL extract administered orally in rats. These results suggest that CL extract may be due to inhibitions of atherogenic index and lipid peroxidation with less triglyceride, total and LDL cholesterol levels and a larger HDL cholesterol levels, resulting in a greater reduction of cardiovascular disease, and intervention of aging process.
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KEYWORD
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Codonopsis lanceolata, triglyceride, LDL, HDL, atherogenic index, cholesterol
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